| BC Year | Event |
| 334-323 |
Alexander the Great leads Macedonian Conquest of Persia. |
| 335 |
Alexander destroys Thebes when it rebels against Macedonia. |
| 334 |
Alexander invades Persia. Battle of the Granicus delivers Asia Minor. |
| 333 |
Alexander cuts Gordian Knot; Victory at Battle of Issus delivers Syria. |
| 332 |
Siege of Tyre ends in a hard-won victory. Egypt opens its doors to Alexander. |
| 331 |
Alexander meets Darius III in Battle of Guagamela (aka Arabela) —conquers all of Persia. |
| 327 |
Alexander invades central Asia and conquers India at the Battle of Hydaspes. |
| 323 |
Death of Alexander and the division of his Empire. |
| 322 |
Demosthenes kills himself after failure of Greek Rebellion against Macedonia. |
| 321-280 |
Wars of the Diadochi fought among Alexander's generals over control of his empire. |
| 331 |
Ptolemy I wins control of Egypt at the Battle of Pelusium. |
| 302 |
Seleucus wins control of Syria at the Battle of Ipsus, Antigonus I is killed. |
| 281-271 |
Pyrrhus Conquers Southern Italy and much of Greece but fails to hold his territory. |
| 200-146 |
Roman Macedonian Wars are fought for control Greece. |
| 197 |
Romans punish the Macedonians for supporting Hannibal at the Battle of Cynoscephalae. |
| 168 |
Romans, under Aemilius Paulus conquer Macedonia at the Battle of Pydna. |
| 226-146 AD |
Achaean League Civil Wars are fought among Greek city states for control of the Peloponnese. |
| 226 |
Spartans, under Cleomenes III destroy the Achaean league capital of Megalopolis. |
| 221 |
The Achaeans, led by Aratus, ally with Macedonia to defeat Sparta. |
| 183 |
Achaean League under Philopoemen defeats Nabis, the tyrant of Sparta. |
| 146 |
Achaean League resists Roman domination and is defeated. Corinth is destroyed. |